SCIENCE & RESEARCH

Propionibacterium freudenreichii UF1 (P.UF1™)

Propionibacterium freudenreichii UF1 (P.UF1™) was discovered at the University of Florida by Dr. Mansour M. Zadeh, by a prominent immunologist with over 27 years of expertise in the fields of inflammation, systemic/mucosal immunology, infection, and microbiome biology.

Bacteria with bifidogenic properties are the most prevalent species in the microbiome of infants. The surprising discovery of P.UF1™ inspired the researcher’s interest to further elucidate the immune status and gut health benefits of this unique strain to illuminate importance of this bacterium in controlling the host homeostasis in health and induced local and peripheral inflammation.

P.UF1™ is a next generation probiotic strain positioned to disrupt the stagnant probiotic category, by providing novel benefits unlike common lactobacilli or bifidobacterial currently in the market.

Dr. Mansour M. Zadeh

Formula-feeding (FF) results in critical differences in the microbiota composition of infants compared to human breast milk-feeding (HBMF).

Formula-fed infants have a reduced microbial richness and diversity.

Formula-feeding results in the absence of Propionibacteria.

Breast-milk-feeding specifically increases Propionibacteria freudenreichii in the newborn’s gut.

Reference: N. Colliou, Y. Ge, B. Sahay, et al. Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation. J Clin Invest. 2017, 127(11):3970–3986.

How does human breast milk promote infant immune health? P.UF1™ is the key.

Transfaunation of microbiota from FF plus Propionibacterium freudenreichii P.UF1™ or HMB-fed (naturally containing P.UF1™) preterm infants to germfree mice conferred protection against pathogen infection and correlated with profound increases in intestinal protective Th17 cells and Tregs.

Reference: N. Colliou, Y. Ge, B. Sahay, et al. Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation. J Clin Invest. 2017, 127(11):3970–3986.

P.UF1™ reduced loss in body weight and diarrhea in mice with chemically-induced colitis.

P.UF1™ significantly improved colitis score.

Reference: Y. Ge, M. Gong, M. Zadeh, et al. Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation. Mucosal Immunology 2020, 13:34–46.